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AGR MCP Server

Enables querying of genomics data from the Alliance of Genome Resources, providing access to gene functions, disease associations, and expression data across major model organisms including humans, mice, and zebrafish.

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1
Tools
11
Updated
Dec 16, 2025

AGR MCP Server

MCP server for querying Alliance of Genome Resources - genomics data across model organisms.

Installation

Option 1: npx (Recommended)

No installation required. Add to your MCP client config:

{
  "mcpServers": {
    "agr-genomics": {
      "command": "npx",
      "args": ["-y", "agr-mcp-server"]
    }
  }
}

Option 2: Global install

npm install -g agr-mcp-server

Then use in your config:

{
  "mcpServers": {
    "agr-genomics": {
      "command": "agr-mcp-server"
    }
  }
}

Config file locations

ClientConfig path
Claude Desktop (macOS)~/Library/Application Support/Claude/claude_desktop_config.json
Claude Desktop (Windows)%APPDATA%\Claude\claude_desktop_config.json
Claude Code~/.claude/settings.json
CursorSettings > MCP Servers
Windsurf~/.codeium/windsurf/mcp_config.json

Usage

Ask questions naturally:

  • "Search for BRCA1 genes in human"
  • "What genes are involved in DNA repair?"
  • "Get information about HGNC:1100"
  • "Find orthologs of insulin gene"
  • "What diseases are associated with TP53?"
  • "Show me expression data for daf-2 in worm"

Supported Species

Human, mouse, rat, zebrafish, fly, worm, yeast, xenopus

Tools

ToolDescription
search_genesSearch genes with optional species filter
get_gene_infoDetailed gene information (symbol, location, synonyms)
get_gene_diseasesDisease associations for a gene
search_diseasesSearch diseases by name
get_gene_expressionExpression data across tissues/stages
find_orthologsCross-species homologs
get_gene_phenotypesPhenotype annotations
get_gene_interactionsMolecular and genetic interactions
get_gene_allelesAlleles/variants for a gene
search_allelesSearch alleles by name
get_species_listList supported model organisms

Gene ID Formats

SpeciesFormatExample
HumanHGNC:*HGNC:1100
MouseMGI:*MGI:95892
RatRGD:*RGD:3889
ZebrafishZFIN:ZDB-GENE-*ZFIN:ZDB-GENE-990415-72
FlyFB:FBgn*FB:FBgn0000017
WormWB:WBGene*WB:WBGene00000898
YeastSGD:S*SGD:S000002536
XenopusXenbase:XB-GENE-*Xenbase:XB-GENE-485905

Data Sources

License

MIT

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