🧬 ARIA Clinical Research MCP Server

A standalone MCP server that gives any Claude agent real-time access to biomedical literature and clinical trials — no API keys required.

Tools

Tool	Description
`search_pubmed`	Search 35M+ peer-reviewed papers via NCBI E-utilities
`search_clinical_trials`	Search 400K+ trials via ClinicalTrials.gov v2 API

Resources & Prompts

Resource info://aria — server capabilities overview
Prompt clinical-research-brief — reusable prompt template for structured clinical intelligence briefs

Example queries

Once connected, ask Claude:

"Search PubMed for ketogenic diet pediatric epilepsy outcomes"
"Find recruiting trials for lung cancer immunotherapy"
"What does the literature say about veliparib in ovarian cancer, and are there active trials?"

Quickstart

git clone https://github.com/pkotecha-eng/aria-mcp-server
cd aria-mcp-server
pip install -r requirements.txt
python3 server.py

Connect to Claude Desktop

Add to ~/Library/Application Support/Claude/claude_desktop_config.json:

{
  "mcpServers": {
    "aria-clinical-research": {
      "command": "python3",
      "args": ["/absolute/path/to/aria-mcp-server/server.py"]
    }
  }
}

Restart Claude Desktop. The server will appear under Settings → Developer → Local MCP Servers.

Data sources

PubMed — NCBI E-utilities (public API, no key required)
ClinicalTrials.gov — v2 REST API (public API, no key required)

Tech stack

FastMCP — MCP server framework
Python 3.12+

Use cases

Life sciences researchers needing real-time literature access
Clinical trial coordinators checking eligibility and recruiting status
Drug discovery teams cross-referencing published evidence with active trials
Any Claude agent needing grounded biomedical knowledge

Built by

Pooja Kotecha · dinq.me/pkotecha-eng

aria-mcp-server