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VirtualFlyBrain

MCP server for Drosophila neuroscience data from VirtualFlyBrain

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Feb 7, 2026

VFB3-MCP Server

A Model Context Protocol (MCP) server for interacting with VirtualFlyBrain (VFB) APIs. This server provides tools to query VFB data, run queries, and search for terms.

🚀 Quick Start

Use the Live Service (Recommended)

The easiest way to use VFB3-MCP is through our hosted service at https://vfb3-mcp.virtualflybrain.org. This requires no installation or setup on your machine.

Claude Desktop Setup

  1. Open Claude Desktop and go to Settings
  2. Navigate to the MCP section
  3. Add a new MCP server with these settings:
    • Server Name: virtual-fly-brain (or any name you prefer)
    • Type: HTTP
    • Server URL: https://vfb3-mcp.virtualflybrain.org

Configuration JSON (alternative method):

{
  "mcpServers": {
    "virtual-fly-brain": {
      "url": "https://vfb3-mcp.virtualflybrain.org"
    }
  }
}

Claude Code Setup

  1. Locate your Claude configuration file:

    • macOS/Linux: ~/.claude.json
    • Windows: %USERPROFILE%\.claude.json
  2. Add the VFB3-MCP server to your configuration:

{
  "mcpServers": {
    "virtual-fly-brain": {
      "url": "https://vfb3-mcp.virtualflybrain.org"
    }
  }
}
  1. Restart Claude Code for changes to take effect

GitHub Copilot Setup

  1. Open VS Code with GitHub Copilot installed
  2. Open Settings (Ctrl/Cmd + ,)
  3. Search for "MCP" in the settings search
  4. Find the MCP Servers setting
  5. Add the server URL: https://vfb3-mcp.virtualflybrain.org
  6. Give it a name like "Virtual Fly Brain"

Visual Studio Code (with MCP Extension)

  1. Install the MCP extension for VS Code from the marketplace
  2. Open the Command Palette (Ctrl/Cmd + Shift + P)
  3. Type "MCP: Add server" and select it
  4. Choose "HTTP" as the server type
  5. Enter the server details:
    • Name: virtual-fly-brain
    • URL: https://vfb3-mcp.virtualflybrain.org
  6. Save and restart VS Code if prompted

Other MCP Clients

For any MCP-compatible client that supports HTTP servers:

{
  "mcpServers": {
    "virtual-fly-brain": {
      "url": "https://vfb3-mcp.virtualflybrain.org",
      "type": "http"
    }
  }
}

Testing the Connection

Once configured, you can test that VFB3-MCP is working by asking your AI assistant to:

  • "Get information about the term VFB_jrcv0i43"
  • "Search for terms related to medulla"
  • "Run a PaintedDomains query for VFB_00101567"

If you see responses with VirtualFlyBrain data, the setup is successful!

🛠️ Local Installation

Prerequisites

  • Node.js 18 or higher
  • npm or yarn

Step-by-Step Installation

  1. Clone the repository:

    git clone https://github.com/Robbie1977/VFB3-MCP.git
    cd VFB3-MCP
    
  2. Install dependencies:

    npm install
    
  3. Build the project:

    npm run build
    
  4. Start the server:

    npm start
    

Platform-Specific Setup

Claude Desktop (Local Development)

For local development with Claude Desktop, add this to your MCP configuration:

macOS: ~/Library/Application Support/Claude/claude_desktop_config.json Windows: %APPDATA%\Claude\claude_desktop_config.json

{
  "mcpServers": {
    "vfb3-mcp": {
      "command": "node",
      "args": ["/absolute/path/to/VFB3-MCP/dist/index.js"]
    }
  }
}

Claude Code

Add to your claude.json file:

{
  "mcpServers": {
    "vfb3-mcp": {
      "command": "node",
      "args": ["/absolute/path/to/VFB3-MCP/dist/index.js"]
    }
  }
}

Visual Studio Code

  1. Install the MCP extension for VS Code
  2. Press Cmd + Shift + P (macOS) or Ctrl + Shift + P (Windows/Linux)
  3. Select MCP: Add server…
  4. Choose Command type
  5. Enter:
    • Name: vfb3-mcp
    • Command: node
    • Arguments: /absolute/path/to/VFB3-MCP/dist/index.js

GitHub Copilot

Configure the MCP server URL in your Copilot settings to point to your local server:

http://localhost:3000

For HTTP mode testing:

MCP_MODE=http PORT=3000 node dist/index.js

Docker Installation

Using Docker Compose (Recommended):

docker-compose up --build

Manual Docker Build:

# Build the image
docker build -t vfb3-mcp .

# Run the container
docker run -p 3000:3000 vfb3-mcp

Pull Pre-built Image:

docker pull virtualflybrain/vfb3-mcp:latest
docker run -p 3000:3000 virtualflybrain/vfb3-mcp:latest

Available Tools

get_term_info

Retrieve detailed information about VFB terms using their IDs.

Parameters:

  • id (string): VFB ID (e.g., "VFB_jrcv0i43")

run_query

Execute predefined queries on VFB data.

Parameters:

  • id (string): VFB ID (e.g., "VFB_00101567")
  • query_type (string): Type of query (e.g., "PaintedDomains")

search_terms

Search for VFB terms using the Solr search server.

Parameters:

  • query (string): Search query (e.g., "medulla")

🧠 About VirtualFlyBrain

VirtualFlyBrain (VFB) is a comprehensive knowledge base about Drosophila melanogaster neurobiology, providing 3D images, gene expression data, neural connectivity information, and standardized terminology for fly brain research.

📖 Documentation

📄 License

MIT

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